FELOKLEAR CAPSULE

Since 2014, Feloklear has been known and used by various women across Nigeria to naturally unblock the fallopian tubes without undergoing any invasive medical procedures. Feloklear is made of 100% natural herbs with no negative side-effects on the body, no preservatives or other artificial substances.
Feloklear Capsule
Therapeutic Class: Gynecology/anti-fungal
Dosage Form, Composition & NAFDAC Reg. No.
Feloklear Capsule -500mg, NAFDAC Reg. No. A7-2459L
Pack size: A pack of Feloklear Capsule -500mg contains 60 capsules
Active Ingredients:
· Azadirachtaindica 200mg
· Arctiumlappa 150mg
· Allium sativum 150mg
Pharmacology:
The active ingredients of Feloklear are largely used for:
· Treating vaginal discharge (caused by yeast infection, P.I.D. or Candida albicans),
· Stops flow back of sperm (caused by blockages of the fallopian tubes/hydrosalphinx due to infection)
· Reduces menstrual pains
· Boosts enjoyment of intimacy
· Reduces foul odours (in the vagina)
· Improves vaginal cleanness
· And generally helps to cleanse the womb and prepare the body for conception
Contra-indications:
Feloklear Capsule should not be taken with any therapeutic drugs like anti-malaria, anti-fungal, etc except vitamins and food supplements. The active ingredients in Feloklear may react with most therapeutic drug ingredients.
Precautions/warning
Feloklear Capsule is not to be used by a lactating mother and pregnant women. If you are using Feloklear and you are trying to conceive, careful monitoring is advised so that you can stop the capsule once pregnancy is confirmed. For children less than 18 years, one capsule is recommended instead of the usual 2*2.
Adverse Effects/Reactions
Feloklear Herbal Capsule is well tolerated. In a clinical trial using 2 capsules morning and 2 capsules at night daily (500mg per capsule), the overall incident of adverse reaction was approximately 5%, with vomiting, heart burn and increased farting.
Do not use Feloklear Capsule with any soft drink or other types of carbonated drinks.
Dosage & Administration
Feloklear Capsule is best taken orally and the recommended dosage is two capsules with warm or normal water 10 minutes before breakfast and two capsules 10 minutes before dinner. Feloklear Capsule should be taken for 2 months (Recommended packs is 4 packs).
Storage Condition:
Store in a cool dry place & do not freeze. Keep out of the reach of children.
Shelf Life:
2 years from the date of manufacturing.
Mechanism of action for Feloklear Capsule
Azadirachtaindica:It also known as Neem; it is a member of the Meliaceae family. It shows its health benefits due to its rich antioxidant, antimicrobial, detoxification activity. It is herb which is bitter which shows beneficial effects in clearing the toxins from the body, treating inflammation, anti-pyrexia, promotes healing and improves overall physiology of the body. Its active constituents are; meliacins, bitter triterpenoids, flavonoids and tannins. Research has shown that a compound isolated from petroleum ether extract of neem oil; 9-octadecanoic acid-hexadecanoic acid-tetrahydrofuran-3,4-diyl ester shows a significant antibacterial activity.1Neem leaves show antiviral activity against influenza, herpes2, common cold and polio.3Azadirachtin is an active compound of Neem which shows an anti-inflammatory by interacting with tumour necrosis factor (TNF) by binding its receptors and inhibits the TNF induced immunological response.4 It produces antioxidant and protective activity against hydrogen peroxide-induced oxidative degradation of DNA and red blood cells.5 Owing to its cytotoxic and DNA binding properties the ethanolicneem leaf extract inhibits IGF signalling pathway in breast cancer cell lines.6 A potent snake venom phospholipase A2 inhibitor is isolated from the leave extract of Neem.7 The bark extract of neem has a potential of detoxifying harmful bacteria and eliminating toxins from the body and provide a healthy digestive system.8 It antiparasitic activity is due to its hormonal interference with the life cycle of parasites.9
Arctiumlappa:It is also known as burdock, it has many health benefits due to its anticancer, detoxification, antibacterial, antidiabetic and anti-inflammatory activity. Arctigenin is its active ingredient has the potential to kill the nutrient-deprived cancer cells.10 The extract from its roots protects the cells from harmful toxic substances and lower the chances of mutation of cells.11Lappol F, Diarctigenin and arctigenin are the active components extracted from the roots of burdock, have the potential to inhibit the nitric oxide NO production. NO is produced during inflammatory diseases such as autoimmune diseases, rheumatoid arthritis etc. Therefore, it provides a protective effect and reduces oxidative stress.12 Phenolic constituents such as; caffeic acid and chlorgenic acid extracted from burdock have shown the antiviral activity against herpes virus and adenovirus.13Arctiumlappa is used to treat loss of libido and it is used as an aphrodisiac agent in females.14
Allium sativum:The common name of allium sativum is garlic. Garlic is medicinally used due to its detoxifying, antimicrobial, anticancer, cardioprotective and antidiabetic activity. Allicin is its principal active component. Garlic provides protection against chemical-induced hepatotoxicity, improves antioxidant status and reduces oxidative stress.15 It also reduces lipid peroxidation due to its antioxidant activity. The antibacterial activity of garlic is due to allicin, it has the potential to inhibit the sulfahydryl enzymes16 in bacteria and also provides bacteriostatic activity against vancomycin-resistant strains.17Allicin also provides antifungal17 and antiviral activity.17
References
1. Zhang Y-Q, Xu J, Yin Z-Q, et al. Isolation and identification of the antibacterial active compound from petroleum ether extract of neem oil. Fitoterapia. 2010; 81: 747-50.
2. Tiwari V, Darmani NA, Yue BY and Shukla D. In vitro antiviral activity of neem (Azardirachta indica L.) bark extract against herpes simplex virus type‐1 infection. Phytotherapy Research. 2010; 24: 1132-40.
3. Faccin-Galhardi LC, Yamamoto KA, Ray S, Ray B, Linhares REC and Nozawa C. The in vitro antiviral property of Azadirachta indica polysaccharides for poliovirus. Journal of ethnopharmacology. 2012; 142: 86-90.
4. Thoh M, Kumar P, Nagarajaram HA and Manna SK. Azadirachtin interacts with the tumor necrosis factor (TNF) binding domain of its receptors and inhibits TNF-induced biological responses. Journal of Biological Chemistry. 2010; 285: 5888-95.
5. Manikandan P, Anandan R and Nagini S. Evaluation of Azadirachta indica leaf fractions for in vitro antioxidant potential and protective effects against H2O2-induced oxidative damage to pBR322 DNA and red blood cells. Journal of agricultural and food chemistry. 2009; 57: 6990-6.
6. Elumalai P, Gunadharini DN, Senthilkumar K, et al. Ethanolic neem (Azadirachta indica A. Juss) leaf extract induces apoptosis and inhibits the IGF signaling pathway in breast cancer cell lines. Biomedicine & Preventive Nutrition. 2012; 2: 59-68.
7. Mukherjee AK, Doley R and Saikia D. Isolation of a snake venom phospholipase A2 (PLA2) inhibitor (AIPLAI) from leaves of Azadirachta indica (Neem): Mechanism of PLA2 inhibition by AIPLAI in vitro condition. Toxicon. 2008; 51: 1548-53.
8. Bandyopadhyay U, Biswas K, Sengupta A, et al. Clinical studies on the effect of Neem (Azadirachta indica) bark extract on gastric secretion and gastroduodenal ulcer. Life sciences. 2004; 75: 2867-78.
9. Abdel-Ghaffar F, Al-Quraishy S, Al-Rasheid KA and Mehlhorn H. Efficacy of a single treatment of head lice with a neem seed extract: an in vivo and in vitro study on nits and motile stages. Parasitology research. 2012; 110: 277-80.
10. Tamayo C, Richardson M, Diamond S and Skoda I. The chemistry and biological activity of herbs used in Flor‐Essence™ herbal tonic and Essiac. Phytotherapy Research: An International Journal Devoted to Pharmacological and Toxicological Evaluation of Natural Product Derivatives. 2000; 14: 1-14.
11. Miyamoto Ki, Nomura M, Sasakura M, et al. Antitumor activity of oenothein B, a unique macrocyclic ellagitannin. Japanese Journal of Cancer Research. 1993; 84: 99-103.
12. Wang B-S, Yen G-C, Chang L-W, Yen W-J and Duh P-D. Protective effects of burdock (Arctium lappa Linne) on oxidation of low-density lipoprotein and oxidative stress in RAW 264.7 macrophages. Food Chemistry. 2007; 101: 729-38.
13. Chiang L, Chiang W, Chang M, Ng L and Lin C. Antiviral activity of Plantago major extracts and related compounds in vitro. Antiviral research. 2002; 55: 53-62.
14. Lewis WH and Elvin-Lewis MP. Medical botany: plants affecting human health. John Wiley & Sons, 2003.
15. El-Kott AF. Amelioration of Nitrate-induced Hepatotoxicity. J Med Sci. 2012; 12: 85-91.
16. Wills E. Enzyme inhibition by allicin, the active principle of garlic. Biochemical Journal. 1956; 63: 514.
17. Jonkers D, Sluimer J and Stobberingh E. Effect of garlic on vancomycin-resistant enterococci. Antimicrobial Agents and Chemotherapy. 1999; 43: 3045-.
